OSI-906

Manufacturer supply top purity OSI-906 867160-71-2 with ISO standards We provide high quality OSI-906 (CAS 867160-71-2), at a very affordable prices to our customers.

1.What is the OSI-906 ?

The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition. Linsitinib is a dual inhibitor of IGF-1R and InsR kinases (IC50s = 35 and 75 nM, respectively). It also inhibits InsR-related receptor (IC50 = 75 nM) but is without effect (IC50 > 10 μM) against a large panel of other kinases. Linsitinib inhibits proliferation of a variety of tumor cell lines in vitro and has antitumor efficacy in an IGF-1R-driven xenograft mouse model when administered orally. A rapid, non-invasive method to predict the pharmacodynamic response to linsitinib has been reported.

Linsitinib is a small-molecule dual insulin-like growth factor-1 receptor (IGF-IR) and insulin receptor (IR) kinase inhibitor. IGF-I receptor (IGF-IR) has been implicated in the promotion of tumorigenesis, metastasis and resistance to cancer therapies and thus Linsitinib may be a useful anticancer agent. Potent IGF-1R inhibitor.

2.What is the CAS number for OSI-906 ?

The CAS number of OSI-906 is 867160-71-2.

More information of OSI-906 867160-71-2 are:

3.What is the molecular formula of OSI-906 ?

The chemical formula of?OSI-906 is C26H23N5O which containing 26 Carbon atoms,23 Hydrogen atoms,5 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight, and the molecular weight of OSI-906 is 421.502

4.What is OSI-906(867160-71-2)used for?

The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition. Linsitinib is a dual inhibitor of IGF-1R and InsR kinases (IC50s = 35 and 75 nM, respectively). It also inhibits InsR-related receptor (IC50 = 75 nM) but is without effect (IC50 > 10 μM) against a large panel of other kinases. Linsitinib inhibits proliferation of a variety of tumor cell lines in vitro and has antitumor efficacy in an IGF-1R-driven xenograft mouse model when administered orally. A rapid, non-invasive method to predict the pharmacodynamic response to linsitinib has been reported.

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5.Manufacturer supply top purity OSI-906 867160-71-2 with ISO standards

Wuhan Dahua Pharmaceutical Co.,Ltd. is a quality supplier of OSI-906. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on OSI-906 867160-71-2.